Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases
نویسندگان
چکیده
منابع مشابه
Drug sensitivity and sphingolipid metabolism in CLL.
Management and outcome of patients with CLL have changed during the past decade due to improvements in molecular diagnostics and the implementation of targeted drug therapy.2,3 This rapid progress was due to the discovery of chromosomal changes, the understanding of the prognostic impact of the mutational status of immunoglobulin heavy chain genes, the discovery of prognostic markers and potent...
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Defeating pancreatic cancer resistance to the chemotherapeutic drug gemcitabine remains a challenge to treat this deadly cancer. Targeting the sphingolipid metabolism for improving tumor chemosensitivity has recently emerged as a promising strategy. The fine balance between intracellular levels of the prosurvival sphingosine-1-phosphate (S1P) and the proapoptotic ceramide sphingolipids determin...
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Di-(2-ethylhexyl)-phthalate (DEHP), the most widely utilized industrial plastizer and a ubiquitous environmental contaminant, can act on peroxisome proliferators-activated nuclear hormone receptor family (PPAR) isoforms. To understand the contribution of sphingolipid metabolism to DEHP-induced hepatotoxicity, effect of DEHP exposure on activities of sphingolipid metabolic enzymes in rat liver w...
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I T is my intent to gather together facts pertaming to the lipidoses which might serve to focus on current problems and to call attention to possible therapeutic approaches. The particular lipidoses to be discussed involve the accumulation in tissues of sphingolipids and may be referred to as sphingolipidoses. They may be classified as “inborn errors of sphingolipid metabolism” on the basis tha...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2011
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.2011.01279.x